Spicy Southern Cheesy Chicken

Featured in: Everyday Family Meals

This comforting Southern casserole combines tender chicken with spaghetti, sharp cheddar cheese, and a lively mix of spices. Cream of chicken soup adds richness, while green onions and colorful bell peppers bring freshness and crunch. After baking, the dish emerges golden and bubbly, ready to be served for family gatherings or cozy weeknight dinners. Its simple preparation, creamy texture, and customizable spice level ensure it's a favorite at the table, appealing to both adults and kids alike. Perfect for sharing, and handy for leftovers, this hearty casserole offers a balanced mix of protein, carbs, and cheesy goodness.

Updated on Fri, 31 Oct 2025 14:29:00 GMT
A hearty bowl of Spicy Southern Cheesy Chicken Spaghetti Casserole, bubbling with cheese.  Save to Pinterest
A hearty bowl of Spicy Southern Cheesy Chicken Spaghetti Casserole, bubbling with cheese. | recipesbies.com

Indulge in the heartwarming flavors of Spicy Southern Cheesy Chicken Spaghetti Casserole. This creamy, cheesy dish is layered with tender chicken and zesty spices, making it a perfect comfort food for family gatherings or cozy dinners. With minimal prep time and customizable ingredients, you can create an irresistible meal that will have everyone asking for seconds!

I remember the first time I served this casserole at a Sunday dinner with my family. The rich aroma filled the house as everyone gathered around, and it instantly became a requested favorite at our gatherings!

Ingredients

  • Boneless, skinless chicken breasts: 3 or 4, about 1.5 lbs
  • Spaghetti: 8 oz
  • Sharp cheddar cheese: 2 cups, shredded
  • Fresh bell peppers: 1 cup, chopped
  • Cream of chicken soup: 1 can (10.5 oz)
  • Paprika: 1 tsp
  • Cayenne pepper: 1/2 tsp
  • Garlic powder: 1 tsp
  • Green onions: 1/4 cup, sliced

Instructions

Prep & Oven:
Preheat your oven to 350°F (175°C). Grease a large casserole dish.
Cook Chicken:
Cook the chicken in a large pot over medium heat for about 6,7 minutes per side until golden and cooked through.
Make Pasta:
Boil salted water and cook spaghetti until al dente (8,10 minutes). Drain and set aside.
Mix Ingredients:
In a bowl, mix shredded chicken, cooked spaghetti, cream of chicken soup, bell peppers, spices, and half of the cheddar cheese until well combined.
Bake:
Transfer the mixture to the greased casserole dish and top with remaining cheese. Bake for 25,30 minutes until bubbly and golden brown.
Serve:
Let it rest for 5 minutes before garnishing with chopped green onions and serving.
Deliciously creamy Spicy Southern Cheesy Chicken Spaghetti Casserole, perfect for family dinners.  Save to Pinterest
Deliciously creamy Spicy Southern Cheesy Chicken Spaghetti Casserole, perfect for family dinners. | recipesbies.com

My kids always get so excited when they see this bubbling casserole come out of the oven. Last thanksgiving, it was the first dish everyone reached for!

Nutrition Info

Each serving provides around 380 calories, 24g protein, 36g carbohydrates, and 18g fat. Nutritional values are approximate.

Make Ahead Suggestions

You can prep the casserole in advance and store it in the fridge. Simply bake just before serving for best results.

Serving Ideas

This casserole pairs perfectly with a simple green salad or roasted vegetables on the side.

Cheesy layers of Spicy Southern Cheesy Chicken Spaghetti Casserole topped with green onions. Save to Pinterest
Cheesy layers of Spicy Southern Cheesy Chicken Spaghetti Casserole topped with green onions. | recipesbies.com

Serve this comforting casserole straight from the oven and watch it disappear. It is sure to bring plenty of smiles around your table!

Answers to Recipe Questions

Can I use rotisserie chicken for this casserole?

Yes, shredded rotisserie chicken works well and saves time while maintaining great flavor and texture.

Is it possible to make this dish spicier?

Increase cayenne pepper or add diced jalapeños to intensify the heat to your personal taste.

Can the casserole be prepared ahead of time?

Absolutely. Assemble everything, cover, and refrigerate up to 24 hours before baking for easy meal prep.

What type of cheese is best for this dish?

Sharp cheddar cheese is recommended for its robust flavor and melting quality, but any melting cheese works well.

Can I swap spaghetti for a different pasta?

Yes, substitute spaghetti with other similar pastas like linguine or penne for a different texture.

How do I store leftovers?

Cool and store leftovers in an airtight container in the refrigerator for 3-4 days. Reheat before serving.

Spicy Southern Cheesy Chicken

Creamy, spicy chicken casserole loaded with cheddar, bell peppers and comforting Southern flavors.

Prep duration
15 mins
Time to cook
30 mins
Overall time
45 mins
Published by Sophie Turner


Skill Level Medium

Cuisine Type Southern American

Serves 8 Serving size

Dietary Details None specified

What you need

01 3–4 boneless, skinless chicken breasts (approximately 1.5 pounds)
02 8 ounces dried spaghetti
03 2 cups shredded sharp cheddar cheese
04 1 cup chopped fresh bell peppers
05 1 can (10.5 ounces) cream of chicken soup
06 1 teaspoon paprika
07 1/2 teaspoon cayenne pepper
08 1 teaspoon garlic powder
09 1/4 cup sliced green onions

How to Make It

Step 01

Preheat Oven and Prepare Dish: Preheat oven to 350°F and lightly grease a large casserole dish.

Step 02

Cook Chicken: Heat a large pot over medium heat. Cook chicken breasts for 6–7 minutes per side until golden and fully cooked. Remove and allow to cool slightly.

Step 03

Prepare Spaghetti: Bring a pot of salted water to a boil. Cook spaghetti for 8–10 minutes until al dente. Drain and set aside.

Step 04

Combine Ingredients: Shred cooked chicken. In a large bowl, mix shredded chicken, cooked spaghetti, cream of chicken soup, chopped bell peppers, paprika, cayenne pepper, garlic powder, and half of the cheddar cheese until evenly combined.

Step 05

Assemble and Bake: Transfer mixture into the greased casserole dish. Sprinkle remaining cheddar cheese evenly on top. Bake for 25–30 minutes until bubbling and golden brown.

Step 06

Rest and Garnish: Allow casserole to rest for 5 minutes. Garnish with sliced green onions before serving.

Equipment You'll Need

  • Large pot
  • Casserole dish
  • Mixing bowl
  • Cheese grater

Allergy Details

Review all ingredients for allergens, and reach out to a healthcare pro if unsure.
  • Contains milk, wheat, and possible egg ingredients; may contain gluten and dairy.

Nutrition info (by portion)

Nutrition info is for guidance. Please consult a medical expert if you need advice.
  • Total Calories: 380
  • Fat content: 18 g
  • Carbohydrate: 36 g
  • Protein content: 24 g