Cajun Chicken Spinach Alfredo Pasta

Featured in: Cozy Dinner Plates

Experience a comforting blend of Cajun spices and creamy Alfredo sauce in this dish featuring juicy chicken breast, tender fettuccine, and wilted spinach. Succulent chicken is seasoned, seared, and sliced before being combined with a rich sauce made from butter, garlic, cream, and Parmesan. Spinach adds freshness and color, while a sprinkle of parsley and extra cheese completes each serving. Ideal for weeknight dinners, this hearty pasta offers Southern flavor with medium heat and a luscious texture. Serve hot and enjoy with a crisp white wine for the perfect pairing.

Updated on Sat, 25 Oct 2025 15:09:55 GMT
Close-up of creamy Cajun Chicken Spinach Alfredo Pasta with parsley garnish, ready to eat. Save to Pinterest
Close-up of creamy Cajun Chicken Spinach Alfredo Pasta with parsley garnish, ready to eat. | recipesbies.com

This creamy Cajun Chicken Spinach Alfredo Pasta is my answer when I crave something both cozy and lively for dinner. The spicy, juicy chicken pairs with velvety Alfredo sauce and just-tender spinach, all swirled together with fettuccine. It is the kind of dish that feels special but is still easy enough for a weeknight.

The first time I made this, everyone went back for seconds. The leftovers might be even better the next day because the flavors settle in so well.

Ingredients

  • Boneless skinless chicken breasts: tender and quick to cook aim for similar sizes for even results
  • Cajun seasoning: brings signature smoky heat seek a blend without added salt if possible
  • Olive oil: helps brown the chicken and adds rich flavor use extra virgin for best taste
  • Fettuccine or linguine: hugs the creamy sauce beautifully look for bronze-cut pasta for best sauce cling
  • Unsalted butter: forms the classic Alfredo base choose a high-quality one for depth
  • Fresh garlic: infuses aromatic warmth firm cloves are best to avoid bitterness
  • Heavy cream: gives velvety texture and richness use cream with at least 35 percent fat
  • Freshly grated Parmesan cheese: melts smoothly pre-grated can be dry and less flavorful
  • Salt and black pepper: sharpen and balance the creamy sauce use kosher salt for better control
  • Red pepper flakes: open up an extra layer of heat use just a pinch to start for gentle warmth
  • Fresh baby spinach: wilts perfectly in hot sauce and sneaks in extra nutrients seek bright, crisp leaves
  • Fresh parsley: adds a burst of color and herby brightness flat-leaf is the most flavorful
  • Extra fresh Parmesan for topping: lets you customize the cheesy finish

Instructions

Cook the Pasta:
Bring a large pot of salted water to a vigorous boil. Add the pasta and stir occasionally to prevent sticking. Cook until the noodles are just barely al dente which often means one minute less than the package suggests. Reserve half a cup of cooking water then drain and set noodles aside.
Prepare the Chicken:
Pat the chicken breasts completely dry with paper towels so the seasoning sticks. Sprinkle Cajun seasoning evenly on both sides pressing gently for good coverage. Heat olive oil in a heavy skillet over medium-high heat until it shimmers. Set the chicken in without crowding and cook five or six minutes per side. Aim for a golden crust and an internal temp of at least 74 degrees Celsius. Move chicken to a plate let it rest for five minutes to keep juices inside then slice thinly across the grain.
Make the Alfredo Sauce:
In the same pan used for chicken melt the butter over medium heat. Add minced garlic and stir constantly for one minute just until fragrant. Pour in heavy cream and whisk while bringing it to a gentle bubble but not a full boil to avoid separation.
Finish the Sauce:
Add Parmesan cheese salt black pepper and red pepper flakes if using. Whisk until the cheese is fully melted and the sauce is smooth and thick enough to coat a spoon. This takes about two or three minutes.
Wilt the Spinach:
Add the spinach straight to the pan and stir. Let it soften and wilt just enough to stay silky but bright green usually about one minute.
Combine Everything:
Add cooked pasta to the skillet of sauce and spinach using tongs to toss the noodles. Add a splash of reserved pasta water if needed to reach a loose creamy texture.
Serve:
Layer sliced chicken over the pasta or fold it in just enough to warm through. Top with parsley and extra Parmesan. Serve hot for best flavor and texture.
Savory Cajun Chicken Spinach Alfredo Pasta: golden chicken atop fettuccine in rich, cheesy sauce. Save to Pinterest
Savory Cajun Chicken Spinach Alfredo Pasta: golden chicken atop fettuccine in rich, cheesy sauce. | recipesbies.com

When I was first testing this recipe I fell in love with how baby spinach melts ovenlike into the Alfredo keeping everything balanced. My kids always hover near the stove waiting for the fragrant garlic and chicken—you can almost taste the excitement in the air.

Storage Tips

This pasta keeps well in an airtight container for up to three days in the fridge. When reheating add a splash of milk or cream to bring the sauce back together. Avoid microwaving too long which can overcook the chicken and seize the sauce.

Ingredient Substitutions

For a seafood vibe swap chicken for peeled shrimp sauté just until pink. For lower dairy try half-and-half in place of cream or a lactose-free Parmesan. Gluten-free pasta works as long as you watch texture so it does not lose its bite.

Serving Suggestions

This dish shines with a crisp side salad of arugula or baby greens. Garlic bread or warm baguette help mop up every drop of sauce. For a Southern touch offer a side of buttery corn or charred okra.

Cultural and Historical Context

Alfredo sauce made its mark in early twentieth-century Italy as a buttery pasta topping but Louisiana Cajun flavors turn it into a bold American comfort food. That savory backbone of seasoning plus a heavy hand of garlic are signatures of Southern hospitality.

Seasonal Adaptations

In spring stir in fresh peas or chopped asparagus with the spinach for extra brightness In autumn add sautéed mushrooms or roasted red peppers for earthier undertones The core recipe works year-round but add seasonal veg for variety

Success Stories

Every time I serve this at a gathering friends always ask for the recipe. It has now become a birthday request in my house and a few neighbors make it for busy weeknights. My favorite memory is listening to laughter spill from the table as everyone digs in—food really does bring people together.

Freezer Meal Conversion

Prepare the sauce and chicken but hold off on adding the spinach or pasta. Freeze them separately in airtight containers. Defrost in the fridge then reheat gently blending everything just before serving for best texture.

Hot, comforting Cajun Chicken Spinach Alfredo Pasta, swirled on a plate with garlic aroma. Save to Pinterest
Hot, comforting Cajun Chicken Spinach Alfredo Pasta, swirled on a plate with garlic aroma. | recipesbies.com

This pasta brings warmth and a lively twist to your table—and leftovers taste just as wonderful. Serve immediately and enjoy every creamy bite.

Answers to Recipe Questions

What type of pasta works best?

Fettuccine or linguine are ideal, as their broad shape holds Alfredo sauce well.

How spicy is the Cajun seasoning?

Medium spice with a smoky kick. Adjust the amount or omit red pepper flakes for less heat.

Can I substitute chicken with shrimp?

Yes, shrimp cooks quickly and adds a delicious seafood twist to the dish.

Is heavy cream essential for Alfredo sauce?

Heavy cream yields a rich texture, but half-and-half can be used for a lighter option.

What garnishes complement the flavors?

Chopped parsley and extra Parmesan bring freshness and tanginess to the finished pasta.

Is this dish suitable for gluten-sensitive diets?

Use gluten-free pasta and ensure Cajun seasoning and cheese are certified gluten-free.

Cajun Chicken Spinach Alfredo Pasta

Spicy Cajun chicken with creamy Alfredo sauce tossed with spinach and pasta for a hearty Southern-inspired meal.

Prep duration
15 mins
Time to cook
25 mins
Overall time
40 mins
Published by Sophie Turner


Skill Level Medium

Cuisine Type American Cajun-inspired

Serves 4 Serving size

Dietary Details None specified

What you need

Chicken

01 2 boneless, skinless chicken breasts
02 1 tablespoon Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine or linguine

Alfredo Sauce

01 3 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 1/4 cups heavy cream
04 1 cup freshly grated Parmesan cheese
05 1/2 teaspoon salt
06 1/2 teaspoon black pepper
07 1/4 teaspoon red pepper flakes

Vegetables

01 3 cups fresh baby spinach

Garnish

01 1 tablespoon chopped fresh parsley
02 Extra grated Parmesan

How to Make It

Step 01

Cook the Pasta: Bring a large pot of salted water to a rolling boil and cook the fettuccine until al dente following the package directions. Drain, reserving 1/2 cup pasta water. Set pasta aside.

Step 02

Prepare the Cajun Chicken: Pat chicken breasts dry and evenly coat both sides with Cajun seasoning. In a large skillet over medium-high heat, warm the olive oil. Sear chicken for 5 to 6 minutes per side until cooked through and golden brown; internal temperature should reach 165°F. Transfer chicken to a plate, rest for 5 minutes, then slice thinly.

Step 03

Make the Alfredo Sauce: In the same skillet, melt unsalted butter over medium heat. Add minced garlic and sauté for 1 minute until aromatic. Pour in the heavy cream and bring to a gentle simmer.

Step 04

Finish the Sauce: Stir in grated Parmesan, salt, black pepper, and red pepper flakes if preferred. Whisk until cheese melts and the sauce becomes smooth, about 2 to 3 minutes.

Step 05

Wilt the Spinach: Add fresh baby spinach to the Alfredo sauce and cook until just wilted, approximately 1 minute.

Step 06

Assemble the Dish: Add the cooked fettuccine to the skillet, tossing thoroughly to coat with sauce. Gradually stir in reserved pasta water to achieve desired sauce consistency.

Step 07

Incorporate Chicken: Arrange sliced Cajun chicken on top of the pasta or gently fold through before serving.

Step 08

Garnish and Serve: Sprinkle chopped fresh parsley and additional grated Parmesan over the plated pasta. Serve immediately while hot.

Equipment You'll Need

  • Large pot
  • Large skillet
  • Tongs or pasta fork
  • Chef's knife
  • Cutting board

Allergy Details

Review all ingredients for allergens, and reach out to a healthcare pro if unsure.
  • Contains dairy: butter, cream, Parmesan cheese
  • Contains wheat: pasta
  • May contain gluten: pasta, Cajun seasoning, cheese (verify product labels if gluten-sensitive)

Nutrition info (by portion)

Nutrition info is for guidance. Please consult a medical expert if you need advice.
  • Total Calories: 650
  • Fat content: 30 g
  • Carbohydrate: 60 g
  • Protein content: 38 g